Endocrine Abstracts

Parathyroid hormone (PTH) secretion maintains extracellular calcium (Ca2+o) homeostasis under the control of the calcium-sensing receptor (CaR). Supra-physiological pHo changes (±1 pH unit) significantly alter CaR activity in a heterologous expression system. Interestingly, metabolic acidosis and hyperparathyroidism are concomitant in both ageing and chronic kidney disease. Therefore, here we examined whether smaller, pathophysiological pH...